TOC-750S TOC Analyzer
Product introduction
The TOC-750S Total Organic Carbon Analyzer test the total organic carbon concentration in water samples. It can
detect water samples with TOC concentrations ranging from 0.001
mg/L to 100.0 mg/L with high sensitivity, accuracy, and good
stability.
The TOC-750S Total Organic Carbon Analyzer is a simple online testing instrument. The main components are
installed on the main unit. Before measurement, the instrument
needs to be connected to the gas line and the reagents are
prepared. The instrument is controlled by a special software
installed on the instrument display to perform measurement,
calibration, printing and other data processing tasks.
Application
Ø Deionized water samples such as water for injection and purified
water
Ø Cleaning validation for the pharmaceutical industry
Ø Environmental water such as tap water and surface water
Ø Chemical water (washing water, cooling water, recycled water, etc.)
Ø Laboratory research
Working principle
The TOC-750S Total Organic Carbon Analyzer utilizes the UV-persulfate
oxidation-NDIR detection principle. One sample is fully oxidized by
UV and persulfate to produce CO2, while another sample is treated
with an acid reagent to decompose inorganic carbon into CO2. The
CO2 is then dried and cleaned with a carrier gas before entering a
non-dispersive infrared (NDIR) detector for measurement, thereby
determining the carbon concentration in the sample.
Working principle diagram
Test modes
Test Mode | Work method |
TC mode | The TC mode is used to determine the total carbon in the sample.
The sample is decomposed into CO2 in the UV reactor under the
action of oxidant, acid reagent and UV. |
TIC Mode | The TIC mode is used to determine the inorganic carbon (carbonates
and bicarbonates) in a sample. In a UV reactor, the carbonate and
bicarbonate fractions are decomposed into CO2 by the presence of an
acid reagent. |
TOC Mode | TOC mode is used to measure the organic carbon in a sample. TOC is
determined using the subtraction method, i.e., TOC = TC - TIC. TC
and TIC are measured sequentially. The TOC measured using the
subtraction method includes both volatile and nonvolatile organic
carbon. |
NPOC Mode | TOC mode is used to measure the organic carbon in a sample. TOC is
determined using the subtraction method, i.e., TOC = TC - TIC. TC
and TIC are measured sequentially in the sample. The TOC measured
using the subtraction method includes both volatile and nonvolatile
organic carbon. |
Technical parameters
TOC-750S total organic carbon analyzer |
Analytical Method | UV persulfate oxidation-NDIR detection principle |
Detectable Items | TC, IC, TOC, NPOC |
TOC Detection Range | 0.001 mg/L to 100.0 mg/L |
Injection Volume | 50 to 6000 μL |
Carrier Gas | High-Purity Nitrogen (CO2-Free Air) |
Sample Temperature | 0-100°C |
Oxidant | Sodium Persulfate Solution |
Acid | Phosphoric Acid Solution |
Analysis Time | 3-8 minutes |
TOC Accuracy | 0.001 mg/L |
Accuracy Error | ±5% |
Zero Drift | ±2%/D |
Repeatability Error | ≤3% |
Span Drift | ±2%/D |
Ambient Temperature | 0-40°C |
Power Supply | 220 ± 22 V AC, 50 ± 1 Hz |
Relative Humidity | ≤85% |
Power Consumption | 150 W |
Dimensions | 42 cm × 36.5 cm × 38 cm |
Weight | 21 kg |
Features
Complies with the requirements of EP, USP, and the 2020 edition of
the Chinese Pharmacopoeia.
Four detection modes: TC, TIC, TOC, and NPOC, all performed in a
single reactor.
A highly reflective gold-plated gas chamber, a highly concentrated
infrared light source, and a highly sensitive infrared detector
ensure excellent NDIR performance, enabling sensitive and accurate
measurements down to the ppb level.
A precision electromagnetic metering pump ensures accurate and
stable injection volume.
Dual-pass electronic condensation dehydration technology.
Real-time visualization of detection curves for enhanced
visualization.
Real-time self-monitoring of temperature, pressure, and flow at
multiple locations.
Customizable curves can be customized to meet the measurement needs
of any water sample.
Optional online module enables online monitoring.
Optional autosampler allows for unattended operation, saving
manpower and time.
Standards
Ø USP <643> Total Organic Carbon (TOC) Method
Ø Chinese Pharmacopoeia 2020 Edition, Part IV, 0682, Determination of
Total Organic Carbon in Water for Injection
Ø GMP Appendix: Computerized System Validation
Ø 21 CFR Part 11
Software
The software meets GMP computer system validation requirements:
Electronic Signature
1) Login via unique username and password.
2) Password length requirements enhance security.
3) A manual lock screen function ensures unique and secure
operation.
Permission Management
1) Multi-level permission settings.
2) Administrators can grant different permissions to other
operators, ensuring that personnel only have permissions
commensurate with their job responsibilities.
Data Integrity
1) Audit trail functionality is available and cannot be disabled.
2) All test results are saved and cannot be modified or deleted.
3) All operations are logged (all access records are kept).
4) If a test method is modified, the modified parameters are
recorded.
5) Data can be exported and backed up to protect stored data for
future use.
Measurement interface:
1) Real-time display of measurement curves for greater clarity
2) Automatic calculation of average values
3) Efficient measurement: a single analysis takes only 3 minutes
Report format:
1) Comprehensive sample test report, fully documenting sample
information and measurement data
2) Reports can be printed by year, month, day, or individual sample
information
Adequate Supply
